Studies of the role of PRKD2 in cardiac function and angiogenesis are more limited, but there is some evidence that defective PRKD2 signaling contributes to the development of human hypertrophic cardiomyopathy (Tsybouleva et al., 2004) and PRKD2 activation of a HDAC5 signaling pathway controls the expression of genes involved in Notch signaling during valve formation in zebrafish embryos (Just et al., 2011). This evidence concerns the gene PRKD2 and hypertrophic cardiomyopathy.