PRKD consists of a family of evolutionarily conserved signal-activated enzymes (PRKD1, PRKD2, and PRKD3) (Valverde et al., 1994; Hayashi et al., 1999; Sturany et al., 2001) that play critical roles in fundamental biological processes (Manning et al., 2002) and contribute to the pathogenesis of a large number of clinically important diseases, including pancreatitis (Piscuoglio et al., 2016), various cancers (Yuan and Pandol, 2016), human heart failure development and cardiac hypertrophy (Wei et al., 2015). Here, PRKD2 is linked to cardiac hypertrophy.