PRKD2 and acute myeloid leukemia: Moreover, PRKD2 expression has been correlated with key genes involved in Notch pathway in newly diagnosed acute myeloid leukemia (AML) patients (Liu et al., 2019) and there is evidence that PRKD2 promotes proliferation and chemo-resistance of human AML cell lines through a mechanisms involving Notch activity (Liu et al., 2019).