DHRS2 and ocular melanoma: Black’s study was conducted in the USA, and acute OM was the only ear-related outcome.21 The Tregnaghi et al’s study was done in Central and South American countries, but only 7214 children from Panama were included in the OM portion of the study.23 Prymula et al published an acute OM trial using an 11-valent pneumococcal vaccine conjugated to Hemophilus influenzae-derived protein D trial in 4968 subjects.24 This trial was conducted in the Czech Republic and Slovakia, and tympanocentesis and pneumococcal subtyping were done.