Especially, several proteins, such as, ANXA1, CEACAM5 (aka CEA), VIM, ALB1 and IL6, have been reported to be potential biomarkers in the diagnosis of ESCC, [24, 25, 29–32] however, most proteins on the Oncology II panel have not yet been examined for their expression in ESCC blood samples. This evidence concerns the gene IL6 and esophageal squamous cell carcinoma.