Especially, several proteins, such as, ANXA1, CEACAM5 (aka CEA), VIM, ALB1 and IL6, have been reported to be potential biomarkers in the diagnosis of ESCC, [24, 25, 29–32] however, most proteins on the Oncology II panel have not yet been examined for their expression in ESCC blood samples. The gene discussed is CEACAM5; the disease is esophageal squamous cell carcinoma.