Further investigation into the differences between early-onset Alzheimer’s disease (EOAD, onset < 65y) patients and late-onset Alzheimer’s disease (LOAD, onset > 65y) patients, showed no differences in Aβ load, microglia prevalence, or Aβ-infiltration of C1, C2 nor C3 (Additional file 1: Fig. S4g–q). This evidence concerns the gene C2 and Alzheimer disease.