The importance of BRG1 in cancer is further evidenced through studies of synthetic lethality, where BRG1 was observed to have a synthetic lethal relationship with the alternative SWI/SNF ATPase Braham (BRM), and Aurora A kinase in lung cancer, and PTEN in prostate cancer [43, 47, 48]. The gene discussed is SMARCA4; the disease is prostate carcinoma.