SMARCA4 and cancer: SMARCA4 mRNA was seen to be down-regulated in bladder, colon, non-triple negative breast cancers, head and neck, oesophageal, melanoma, pancreatic, lung and ovarian cancers, and SMARCA4 mutation rates in these cancers have been reported between 4 and 13% [12–14, 22, 24, 30, 39–41].