As BRG1 is known to regulate cell cycle genes in other cancers, such as in leukaemia [24] and breast cancer [98], we speculate it is possible that regulation of cell cycle and DNA replication genes may be a general feature of BRG1 over expression in cancer, while genes co-regulated by BRG1, AR and FOXA1 are important in a prostate cancer context. The gene discussed is SMARCA4; the disease is Familial prostate cancer.