Gut microbiota might influence obesity and its dysregulated immunometabolism by facilitating caloric recovery [13], altering intestinal barrier and immune homeostasis [14], promoting the release of incretins and satiety hormones such as glucagon-like peptide 1 (GLP-1) [15], and regulating intestinal and hepatic gluconeogenesis [16]. This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.