CD274 and neoplasm: Therefore, targeting the subset of immunomodulatory miRNAs, including miR-34, miR-126, miR-155, and the miR-25-93-106b cluster, and dysregulated miRNAs including miR-34, miR-570, miR-20b, miR-21b and miR-130b to regulate the expression of PD-L1 and control tumor immune evasion would be a promising approach to restore antitumor immunity and enhance the therapeutic response in HCC [71, 73, 75–77].