HAVCR2 and hepatocellular carcinoma: Additionally, recent works in the literature have recognized the role of Tim-3 as a potential target in HCC immunotherapy, which might both enhance T cell-induced antitumor immunity and revise macrophage-mediated immunosuppression in the HCC microenvironment, suggesting that future immune checkpoint investigations may focus more on Tim-3 for treatment of HCC or other solid tumors with similar pathogenesis.