CD4 and hepatocellular carcinoma: Similarly, in a specific HCC model involving overexpression of the hepatocyte-specific proto-oncoprotein c-Myc with a methionine and choline-inadequate diet, depletion of CD4+ T cells accelerated the development of HCC [39], but after HCC resection, tumor-infiltrating CD4+ CTLs are known to be independent predictors of disease-free survival.