MAPKAPK5 and neoplasm: In addition, a series of experiments were performed to detect the effect of MK2206, the inhibitor of AKT, on the tumor-promoting effect of MAPKAPK5-AS1, and the results showed that MAPKAPK5-AS1 overexpression enhanced the proliferation, the motility and EMT of Hep3B, and reduced Hep3B cell apoptosis, which could be partially reserved by MK2206 treatment (Additional File 10: Fig. S8).