AKT1 and non-small cell lung carcinoma: In non-small cell lung cancer cells, KDM5A promotes HIF-1α-VEGF-induced angiogenesis through Akt and induces the epithelial-mesenchymal transition via down-regulating E-cadherin expression and up-regulating N-cadherin and snail expression through activating Akt [25, 102].