MMP9 and neoplasm: At mRNA level, there was a significant decrease of MMP-9 in tumors from ILEI KD cells (Fig. 6g) and quantification of MMP-9 immunohistochemistry in tumor sections showed a similar trend with a significant difference between the shCont tumors and those with ILEI KD and crizotinib in combination (Fig. 6h, i).