However, in accordance with some earlier findings [26], we observed that inhibition of c-MET with crizotinib reduced the growth and tumor mass of both of the xenografts (Fig. 6a, b, j, k), indicating that crizotinib was able to counteract the resistance of NCI-H441 cells most probably via non-cell intrinsic mechanisms not addressed here. The gene discussed is MET; the disease is neoplasm.