Also, since this model is based on a relatively short-term induction- and treatment period (4 weeks on NASH-diet, 1 week for STZ-induction of hyperglycemia, followed by additional 4 weeks treatment with insulin or vehicle), it would be interesting to evaluate how the induced phenotype progress during a longer time span, and also if the treatment effects are caused by prevention or reversal of progressive liver disease. The gene discussed is INS; the disease is liver disorder.