In the study by Suppli et al., it is for example surprising that expression of several genes associated with monocyte recruitment and inflammation such as Ccr1, Cd14, Cd68, Cd86, Col6a2 and Tlr4 were not upregulated in NASH vs NAFL, although these genes have been implicated in progression of NASH [86–90] and were also upregulated in NASH-STZ hamsters. This evidence concerns the gene TLR4 and metabolic dysfunction-associated steatohepatitis.