Our Western blot results indicated that silencing circ_0082182 decreased the levels of pGSK3β/GSK3β and nucleus β-catenin by increasing miR-411 and miR-1205, manifesting that circ_0082182 could activate the Wnt/β-catenin pathway via targeting miR-411 and miR-1205 in CRC cells. This evidence concerns the gene GSK3B and colorectal carcinoma.