SNHG3 and hepatocellular carcinoma: Lu et al. stated that SNHG3 expression was higher in highly metastatic HCC cells (HCCLM3) than lowly metastatic HCC cells, such as Hep3B and PLC/PRF/5.Besides, SNHG3 also plays important roles in regulating drug resistance: high SNHG3 expression leads to poor survival and sorafenib resistance in hepatocellular carcinoma [25].