NPM1 and acute myeloid leukemia: CR probability was also negatively affected by age of ≥55 years (89/143, 62.2% vs. 82/99, 82.8%; p=0.0005), secondary AML (33/71, 46.5% vs. 138/171, 80.7%; p<0.0001), unfavorable cytogenetics (33/61, 54.1% vs. 129/168, 76.8%; p=0.0008), CD34 positivity (69/121, 57% vs. 102/121, 84.3%; p<0.0001), and NPM1-wt (101/159, 63.5% vs. 64/74, 86.5%; p=0.0003).