The clinical relevance of the small but statistically significant increase in LDLc and apoB after consuming the diet containing HOSBO compared to the diet containing SBO remains unclear given that most other markers of CHD risk were not different between these two diets, including Lp(a), non HDLc, and small LDL particles, as well as the ratios of TC:HDLc, LDLc:HDLc, and apoB:apoAI. The gene discussed is APOA1; the disease is coronary artery disorder.