While the number and distribution of late endosomes (LAMP1 punctate staining) was not affected, EEA1 labeling revealed significantly less early endosomes following viral infection (S2C and S2D Fig) and GFP-tagged Sec61β, used as a marker of ER morphology, remained similarly distributed in infected and uninfected cells (S2E Fig) suggesting that no major ER morphology changes occur during H1N1 infection. This evidence concerns the gene SEC61B and viral infectious disease.