Furthermore, additional studies are needed to better understand if (i) monocytes/macrophages are exposed to SARS-CoV-2 via direct infection via ACE2 binding or through phagocytosis; (ii) ACE2 is induced in infected monocytes and bystander cells through secretion of inflammatory mediators; and (iii) expression of additional host entry receptors such as CD147 and Neuropilin-1 may be expressed in monocytes to facilitate infection in an ACE2-independent manner [69]. This evidence concerns the gene ACE2 and infection.