To elucidate the genetic mechanisms involved in the downregulation of PAICS in CRC, we utilized not only the TCGA cohort (n = 578) but also an additional microarray dataset of human CRC cell lines (the CCLE cohort, n = 57) (S1 Table), in which genomic data, including mutations and somatic copy number alterations (SCNAs) were available through cBioPortal. Here, PAICS is linked to colorectal carcinoma.