PAICS and colorectal carcinoma: Strikingly, prognostic impact of PAICS expression was particularly remarkable in patients with stage III CRC, demonstrating significant association between PAICS-Low tumors and poor relapse-free survival in the MSK cohort (P = 0.0029, Fig 3B), the CIT cohort (P = 0.0280, Fig 3D), and the Oslo cohort (P = 0.0002, Fig 3F).