Correspondingly, the similar findings were obtained in both the CIT cohort (r = -0.13, P<0.01, Fig 1C) by Affymetrix microarray and the TCGA cohort (r = -0.11, P<0.01, Fig 1D) based on RNA-seq, showing a weak but significant negative correlation between the expression of PAICS and tumor progression. The gene discussed is PAICS; the disease is neoplasm.