Of 235 adjacent non-tumor tissues available for evaluation, only 30 (12.8%) were considered positive for PAICS expression, while 179 of 252 CRC tissues (71.0%) were found to be PAICS-positive (P<0.0001, Fig 2E), further confirming the overexpression of PAICS in tumor at protein levels. The gene discussed is PAICS; the disease is colorectal carcinoma.