PAICS and colorectal carcinoma: In patients with stage II CRC, decreased levels of PAICS expression were significantly or marginally associated with worse relapse-free survival in the MSK cohort (P = 0.0342, Fig 3A) and in the CIT cohort (P = 0.0449, Fig 3C), but it was not significant in the Oslo cohort (P = 0.8703, Fig 3E).