CHIKV infections did not significantly affect the expression of 15-PGDH mRNA at 6h whereas CHIKV at the MOI of 10−1 significantly decreased by 7-fold (p<0.001) 15-PGDH mRNA levels at 24h post-infection (6.40x 10−5± 2.21x10-5) versus (4.71x 10−4± 5.73x10-5) in mock-infected control cells. The gene discussed is HPGD; the disease is infection.