TGFB1 and neoplasm: Hereafter, in order to calculate the population of cells (tumor cells, N1 TANs, N2 TANs) and level of chemical variables (CXCL-8, TGF-β, NET/NE, DNase, MMPs) at various times in the mathematical model, we integrate the density and concentration over the space: density of tumor cells (n^(t)=∫Ωn(x,t)dx), N1 TANs (N^1(t)=∫ΩN1(x,t)dx), N2 TANs (N^2(t)=∫ΩN2(x,t)dx), and concentrations of ECM (ρ^(t)=∫Sρ(x,t)dx), CXCL-8 (C^(t)=∫ΩC(x,t)dx), TGF-β (G^(t)=∫ΩG(x,t)dx), NET/NE (E^(t)=∫ΩE(x,t)dx), DNase I (D^(t)=∫ΩD(x,t)dx), and MMPs (P^(t)=∫ΩP(x,t)dx).