In our model, CXCL-8 knockdown leads to critical reduction of chemotactic movement of the neutrophils, which in turn reduces tumor growth (blue curve; CXCL8 KO, Fig 10A) and invasion (red; CXCL8 KO, Fig 10B) compared to control due to decreased activities of NE (∼40%) and TGF-β (∼50%). The gene discussed is CXCL8; the disease is neoplasm.