We aimed to fill this gap by conducting a two‐stage case‐control study to explore never‐smoking female NSCLC‐susceptibility and 12 genomic regions associated with plasma SHBG concentrations, including 1p13.3, 2p16.3, 2p23.3, 4q13.2, 7q21.3, 8q21.13, 10q21.3, 12p21.1, 15q26.2, 17q21.32, 17p13.1, and Xq22.3, which were all identified by a GWAS meta‐analysis.13 Here, SHBG is linked to non-small cell lung carcinoma.