As mentioned in the Introduction section of this paper, the biological effects of Alox15 are related with the lipid mediators generated by Alox15. To elucidate the profile of lipid metabolites produced by Alox15 in the CKD kidney, we examined and compared the sham and 5/6 Nx kidney samples by LC–MS/MS-based mediator lipidomics to determine the lipid mediator profiles between WT mice and Alox15−/− CKD mice (Supplementary Table 1). Here, ALOX15 is linked to chronic kidney disease.