ALOX15 and arthritic joint disease: For instance, ALOX15, a major subtype of LOX, has a dual aspect of proinflammatory and anti-inflammatory properties through its metabolites [5]: ALOX15 is highly expressed in eosinophils, bronchoalveolar epithelial cells and alveolar macrophages under nonpathological condition [5, 6], and promotes severity of asthma [7], lung injury [8], and heart failure [9], whereas it counteracts inflammation in arthritis [10] and ischemic brain [11].