HPGDS and chronic kidney disease: Besides 14-HDoHE, 17-HDoHE, and 15-HEPE, the levels of 18-HEPE, 10-HDoHE, 11-HDoHE, 13-HDoHE, 16-HDoHE and DGLA were also significantly decreased in Alox15−/− CKD kidneys compared to those in WT CKD kidneys, whereas only PGD2 was significantly increased in Alox15−/− CKD kidneys (Fig. 6).