Likewise, intravitreal delivery of AAVs carrying CjCas9 [134] and LbCpf1 [135] successfully disrupted angiogenesis-associated genes Vegfa and Hif1a in the mouse retina, which substantially decreased the excessive choroidal neovascularization in a transgenic model for age-related macular degeneration (AMD) [134, 135]. The gene discussed is HIF1A; the disease is age-related macular degeneration.