Colasante et al. reported that guided transcription activation using AAV-delivered dCas9-VP64 upregulated Scn1a gene expression to attenuate seizures in a Scn1a haploinsufficiency mouse model of Dravet syndrome [154]. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.