Our results showed that EDA-A2-encoding transcript accumulated to higher levels in colon tissues, particularly in LP lymphocytes (LPLs) but not in IECs, from DSS-treated miR-494−/− mice compared to those in colon tissues from WT mice (Supplementary Fig. 3h), suggesting that LPLs were the main source of EDA-A2 that inhibited the proliferation of colonic crypt stem cells in colitis. This evidence concerns the gene EDA and colitis.