Thus, our findings suggested that in the brain death-related acute response, regulation of CTGF expression in HSCs is mediated by YAP in the non-steatotic liver, while in the CCl4-induced liver fibrosis and the non-alcoholic steatotic liver is still dominated by TGF-β or TGF-β induced proline-rich tyrosine kinase 2 pathway35,37. The gene discussed is TGFB1; the disease is Hepatic fibrosis.