RA-FLSEmpty vector and RA-FLSSTAT3C seeded in 96-well plates (5,000 cells/well) were separately pre-treated with RLE (0, 150, 300 μg/mL) for 1 h and then treated with IL-6/sIL-6R for 48 h. The gene discussed is IL6R; the disease is rheumatoid arthritis.