Tumor latency was also affected as a result of loss of WAVE3 or re-expression of PRD-DM; tumors in these mice were palpable 30 and 35 days post implantation, while in the mice implanted with the parental cells or the PRD-WT cells tumor latency was reduced to 21 days post implantation (Fig. 4C). This evidence concerns the gene PEPD and neoplasm.