While the studies by Burk et al.53 and Korpal et al.57 have identified a negative feed-back loop between ZEB1/ZEB2 and members of the miR200 family that regulates EMT and cancer cell invasion, while the report by Teng and colleagues have shown that WASF3 (WAVE3) regulates the ZEB1-mediated inhibition of miR-200, and the subsequent activation of BC invasion cells29. This evidence concerns the gene ZEB1 and breast cancer.