Reactivity to a mutated peptide from SP100 (a tumor suppressor gene) was restricted to the DP CD8+ TIL (Fig. 6d, e; HNOX04), whereas in HNOX07 there was reactivity in both SP and DP cells to mutated PPP1R13L (inhibitor of p53) (Fig. 6f, g). This evidence concerns the gene CD8A and neoplasm.