However, when DN, SP, and DP cells from HNOX18 were screened against peptides from HPV16 and HPV18 E6 and E7 proteins (tumor-associated antigens), we observed a strong response to HPV16 E6 and E7 only in the DP CD8+ T-cell subset (Fig. 6a, b). The gene discussed is CD8A; the disease is neoplasm.