Finally, using integrated ChIP-seq and RNA-seq analyses, we defined the gene signature directly activated by ZM in HSPCs (Fig. 3h and Supplementary Data 4), as well as the “stemness” signature directly activated by ZM (Supplementary Fig. 4h and Supplementary Data 4), which again include AML-related TFs– Hoxa, Meis1, Myc, Myb and Sox4. This evidence concerns the gene MEIS1 and acute myeloid leukemia.