Interestingly, in addition to ZM seen in AML patients, several components of the NuA4/TIP60 complex including MBTD1 were frequently involved in aberrant chromosomal rearrangements detected in endometrial stromal sarcomas, highlighting a broader role for this group of chromatin regulators in oncogenesis23,24. The gene discussed is MBTD1; the disease is acute myeloid leukemia.