Finally, using integrated ChIP-seq and RNA-seq analyses, we defined the gene signature directly activated by ZM in HSPCs (Fig. 3h and Supplementary Data 4), as well as the “stemness” signature directly activated by ZM (Supplementary Fig. 4h and Supplementary Data 4), which again include AML-related TFs– Hoxa, Meis1, Myc, Myb and Sox4. Here, SOX4 is linked to acute myeloid leukemia.