ZM-induced phenotypes were found to be typical of AML— the bone marrow and spleen of leukemic mice were filled with myeloblasts (Fig. 1p, q) that expressed the exogenously introduced ZM fusion (Fig. 1r, top panel) and the surface markers of immature myeloid progenitors (Fig. 1s, cKit+Mac1+). The gene discussed is KIT; the disease is acute myeloid leukemia.