With the same method, we found 1672 transcripts to be upregulated in ZM-transformed AML cells relative to differentiated hematological cells, and remarkably, 259 (~15%) of them are ‘stemness’-related genes, which include a set of transcription factors (TFs) such as Hoxa cluster, Meis1, Mn1, Prdm5, Gata2, Sox4, Myb, and Myc (Fig. 2a and Supplementary Fig. 3b; Supplementary Data 2). The gene discussed is SOX4; the disease is acute myeloid leukemia.