CD34 and acute myeloid leukemia: AMLs caused by co-expressed ZM and NrasG12D also displayed typical leukemic phenotypes including elevated counts of circulating WBCs (Fig. 1j and Supplementary Fig. 2b), splenomegaly (Fig. 1l and Supplementary Fig. 2c) and massive expansion of AML blasts in bone marrow and spleen (Cd34+/Mac1+; Supplementary Fig. 2d–f).