Following its transduction, ZM conferred both HSC and GMP, but not differentiated myeloid cells, the capacity of in vitro immortalization, with the HSC-derived immortalized cells proliferating slightly faster than those GMP-derived ones (Supplementary Fig. 1g), and these two ZM-immortalized leukemia lines exhibited similar myeloid blast immunophenotype (cKit+/Cd34+/Mac1+) and morphology (Supplementary Fig. 1h, i). Here, KIT is linked to leukemia.