At least 10 types of cancer showed a strong negative correlation, including breast invasive carcinoma, brain lower grade glioma (LGG), skin cutaneous melanoma (SKCM), head and neck squamous cell carcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma, lung adenocarcinoma, liver hepatocellular carcinoma (LIHC), pancreatic adenocarcinoma, glioblastoma multiforme (GBM), and acute myeloid leukemia (LAML) (Supplementary Fig. 7c); of these, high RNF167 expression predicted a poor prognosis in GBM, LAML, SKCM, LGG, and LIHC (Supplementary Fig. 7d). The gene discussed is RNF167; the disease is pancreatic adenocarcinoma.