Correlating with the results obtained in MEF after TGFB1 treatment (Fig. 8d–f), we detected in IPF hLF increased expression of GATA6, MTOR and IGF1 (Fig. 9d), as well as increased levels of pH2A.X and H2A.X in their promoters (Fig. 9e and Supplementary 10b), whereas 5mC levels were reduced (Fig. 9f). This evidence concerns the gene HLF and idiopathic pulmonary fibrosis.