In terms of influential covariates, a number of known risk factors, including age, SpO2, blood pressure, ischaemic and other heart diseases, hypertension, white blood cell count, neutrophils, lymphocytes, high-sensitivity c-reactive protein, creatinine, lactate dehydrogenase, albumin, pH and PCO2, were found to be significantly associated with mortality outcomes in the Optum training fold (Table 2). The gene discussed is CRP; the disease is heart disorder.