PLA2R1 and neoplasm: Though little is known about the functional role of the transmembrane protein PLA2R1 in the cancer and aging contexts14,15, it was shown to increase ROS production and DNA damage accumulation leading to different cellular responses like cell death and cellular senescence16–18, and to different organismal outcome like limiting tumor formation during RAS-induced skin carcinogenesis19 and tumor growth20,21 as well as promoting some marks of premature aging in a murine model of progeria22.