Among these genes, the top three genes from each PBMC subtype, which were altered specifically in the fatal group and not in the infection or recovery group, were TNFSF10 (Trail), RSAD2 (viperin), and HERC5 in B cells, CST7, FCGR3A, and GZMA in T cells, killer cell immunoglobulin-like receptors (KIRs) and SELL in NK cells, CXCL10, CCL2, and CCL3 in monocytes, and type I IFN-inducible ISG20, IRF7, and UBE2L6 in dendritic cells (Fig. 3D). The gene discussed is IRF7; the disease is infection.