Garcia et al. showed that G1/S-specific cyclin-D2 (CCND2), MYC proto-oncogene protein (MYC), B-cell lymphoma 2 (BCL2), and LIM domain only 2 (LMO2) mRNAs were significantly higher in DLBCL plasma samples. Here, LMO2 is linked to diffuse large B-cell lymphoma.