Using DLBCL cell lines, Chen et al. showed that circCFL1 targets the miR-107 target gene HMGB1, resulting in an increased expression of HMGB1, thereby upregulating the phosphorylation levels of p-AKT, p-ERK, and p-STAT3, which are involved in signaling pathways that control cell proliferation and migration [163]. The gene discussed is AKT1; the disease is diffuse large B-cell lymphoma.