Our research showed that osteosarcoma patients with higher expression of PPP2R2A had a worse prognosis, which was consistent with the study by Hein et al. [47] Zhou et al reported that the expression level of RPS6KB1 encoded protein p70S6K was negatively correlated with the progression of osteosarcoma patients. The gene discussed is PPP2R2A; the disease is osteosarcoma.