In the EMT-6 bearing mouse model, YM101 increased the density (the ratio in all viable cells) of tumor infiltrating lymphocytes (TILs) compared to vehicle (p < 0.01), anti-TGF-β (p < 0.05), and anti-PD-L1 (p < 0.05) (Fig. 8a). The gene discussed is TGFB1; the disease is neoplasm.