Specifically, there is an overlap between the smoking-DMPs identified here and those found by Ringh et al. [37] in lung tissue, where 32 of the 952 sites overlap particularly at sites annotated to AHRR and in genes previously found to be associated with cancer (KCNMA1, CDH23, LRP5) [[4, 39, 40]]. The gene discussed is LRP5; the disease is cancer.