EPCAM and Patent ductus arteriosus: One example is the CellSearch system-based diagnostics utilizing EpCAM and cytokeratin expression on isolated epithelial cells, an FDA cleared diagnostics for metastatic breast, colon, and prostate cancer, which was evaluated for the diagnosis of PDA and achieved accuracies ranging 11 ~ 78.5 %, indicating great variation in detection rate for PDA [6].