Gene expression of nerve growth factor IB, also called Nur77, was increased during acute sepsis-induced critical illness (p = 0.01 for 1-day sepsis group), unaltered during the subacute phase (p = 0.6 for 3-day and 5-day sepsis groups) and decreased during prolonged phase (p = 0.001 for 7-day sepsis group) (Fig. 5e). The gene discussed is NR4A1; the disease is Sepsis.