NR3C1 and Sepsis: Gene expression of total GR, through which signaling is known to regulate both POMC and PC1/3, was lower than normal in mice with a longer duration of critical illness (5-day and 7-day sepsis groups, both p < 0.05) (Fig. 5c), whereas the ratio between GRα and GRβ expression was lower than normal only in acute critically ill mice (1-day sepsis group, p = 0.05) (Fig. 5d).