NR4A1 and Sepsis: The differentially altered pituitary gene expression profile of two POMC-activating transcription factors, Nur77 and Tpit, of which the first is positively regulated by CRH-R ligand binding and negatively by GR ligand binding [23] and the second is positively regulated by CRH-R ligand binding but not affected by GR ligand binding [24], confirms the presence of both stimulating CRH and AVP signaling and suppressing GR-ligand-binding-induced signaling, during sepsis.