Gene expression of Tpit (or TBX19), a Nur77-synergistic POMC-activating transcription factor, was decreased during the acute phase (p = 0.002 for 1-day sepsis group) and increased during the subacute (p = 0.02 for 3-day sepsis group) and prolonged phase of sepsis-induced critical illness (p < 0.001 for 7-day sepsis group) (Fig. 5f). The gene discussed is POMC; the disease is Sepsis.