However, previous studies did find that MED13L gene played interesting part in the radio-sensitivity of NSCLC tumor cells, as radiation triggers silencing of MED13L and MED13L suppression decreased their physical interactions and reduced recruitment of acetyltransferase P300 to chromatin via Mediator complex, and they in turn suppressed the activities of multiple oncogenes [20]. Here, EP300 is linked to non-small cell lung carcinoma.