ESR1 and neoplasm: In multivariable logistic regression analysis, histologic subtype (P = 0.015, Mixed types: OR = 0.41, 95% CI 0.19–0.90, P = 0.026; Other types: OR = 0.99, 95% CI 0.57–1.72, P = 0.974), tumor grade (P = 0.007; grade II: OR = 2.08, 95% CI 1.31–3.31, P = 0.002; grade III: OR = 2.29, 95% CI 1.24–4.25, P = 0.008), ER expression (OR = 0.99, 95% CI 0.98–0.999, P = 0.032), PR expression (OR = 0.97, 95% CI 0.97–0.98, P < 0.001), and Ki-67 index (OR = 1.03, 95% CI 1.02–1.04, P < 0.001) were still significantly associated with high-risk RS (Table 2).