Univariable analysis demonstrated that age (P = 0.001), tumor size (P = 0.017), histological subtype (P = 0.006), tumor grade (P < 0.001), ER expression (P < 0.001), PR expression (P < 0.001), Ki-67 index (P < 0.001), and Luminal subtype (P < 0.001) were associated with high-risk RS. Here, ESR1 is linked to neoplasm.