INS and hyperinsulinism: In addition, acute euglycemic hyperinsulinemia decreased fractional UA excretion by 26 % (from 6.1 ± 0.8 % to 4.5 ± 0.6 %) in healthy subjects, indicating that insulin inhibits renal UA excretion [29] and that high UA levels causes insulin resistance by affecting the insulin signaling pathways [22].