The gene promoter of the lncRNA lncRNA-SARCC (lncRNA-suppressing androgen receptor in renal cell carcinoma) is highly methylated in human RCC tissues compared with counterpart normal renal tissues, leading to gene silencing, and lower levels of lncRNA-SARCC expression in RCC tissues predict worse prognosis in patients [61, 62]. The gene discussed is P2RY1; the disease is renal cell carcinoma.