The allelic analysis showed that carriage of the mutant allele A in IL-1β rs1143634 SNP (AOR: 0.66, 95%CI 0.46–0.97; P = 0.032) and mutated allele A in FcγRIIA/CD32 rs1801274 SNP (AOR: 0.68; 95%CI 0.52–0.89; P = 0.005) were associated with protection from clinical malaria. Here, IL1B is linked to malaria.