ICC had a higher rates of ER-positive (95.40% vs. 78.50%, p < 0.001), a higher rate of PR-positive status (89.50% vs. 68.30%, p < 0.001), and a lower rate of HER-2 positive (2.90% vs. 9.30%, p < 0.001). Here, ESR1 is linked to intrahepatic cholangiocarcinoma.