Whilst no cases of IgA-dominant IRGN with positive glomerular staining for NAPlr have been published to date, Kikuchi et al have reported a case of Henoch-Schonlein purpura (IgA vasculitis) with positive staining for NAPlr and plasmin activity in kidney glomeruli.[10] Interleukin-6 (IL-6), a cytokine generally produced during infection, is reported to increase IgA1 synthesis and can also accentuate the degree of galactose deficiency of IgA1.[11] Thus, we suggest that the present case shows glomerulonephritis due to overproduction of Gd-IgA1 induced by infection. The gene discussed is IGHA1; the disease is infection.