Regarding that, the patient had no fever (leukocyte 6.66 × 109/L; blood culture: no bacterial growth was observed), renal insufficiency, and neurological symptoms, and at the same time, the activity of ADAMTS13 was 68% and ADAMTS13 antibody was negative, thrombotic thrombocytopenic purpura (TTP) was also excluded. The gene discussed is ADAMTS13; the disease is Renal insufficiency.