RUNX1 and acute myeloid leukemia: Moreover, a retrospective analysis of 651 AML patients conducted by Wang et al[10] found fewer favorable genetic molecular events in elderly patients with AML and secondary AML patients, such as a CEBPA double mutation, runx1-runxt1t1, etc. A double mutation to the CEBPA gene is detected in leukemia cells during AML transformation, and some cases before transformation to APL were accompanied with a double mutation to the CEBPA gene.[11] However, our patient was negative for the CEBPA double mutation at the first onset, which does not support the possibility of evolution from APL to AML.