The mRNA expression of ARID3A, ARID3B, ARID4B, JARID1B, JARID1C, JARID2 in tumor tissues was more expressive in normal tissues, ARID1B, ARID3C, ARID4A, ARID5A, ARID5B, JARID1A mRNA expression in tumor tissues were lower than that in the normal tissues (p<0.05) (Figure 1A). The gene discussed is KDM5A; the disease is neoplasm.